CSB428H1 Lecture Notes - Lecture 20: Tumor Suppressor Gene, Oncogene, Intron

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Published on 15 Aug 2016
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BIOB11 Thursday, July 21
Lecture 20: Proto-Oncogenes, Oncogenes + Tumor Suppressor Genes
Slide 3 Fig 16-9
Proto-oncogene can have a mutation that leads it to becoming an oncogene
Slide 6
Bottom part of chromo 9 is translocated to bottom part of chromo 22
Brings together two genes that were initially separate to make fusion gene
Reciprocal translocation
- two diff chromos swapping material
BCR/ABL fusion gene
- in many patients w/ CML
Slide 7
1st intron of Abl gene and one of two introns of Bcr gene
- creating slightly diff protein coding regions
Constitutively active = always active
- constantly promoting cell cycling
Slide 9
Almost always phosphate grp comes from ATP
Slide 11
Step 3: see if any chemicals in well have effect on chemical rxn (if what you're looking
for is a chemical reaction)
Also need to put normal cells to see that they aren't killed
Slide 12 Fig 2-52
Gleevec
- had stronger inhibitory effects
Slide 15
Normal cell growth will still continue even if one of two genes is mutated to an inactive
tumor suppressor
Both mutated = loss of growth control
Slide 20 Fig 16-11
Tumor suppressor genes are dominant so just getting one mutant gene means you can still
function normally
- but can develop mutation in second one later
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Document Summary

Proto-oncogene can have a mutation that leads it to becoming an oncogene. Bottom part of chromo 9 is translocated to bottom part of chromo 22. Brings together two genes that were initially separate to make fusion gene. 1st intron of abl gene and one of two introns of bcr gene. Almost always phosphate grp comes from atp. Step 3: see if any chemicals in well have effect on chemical rxn (if what you"re looking for is a chemical reaction) Also need to put normal cells to see that they aren"t killed. Normal cell growth will still continue even if one of two genes is mutated to an inactive tumor suppressor. Both mutated = loss of growth control. Tumor suppressor genes are dominant so just getting one mutant gene means you can still function normally. But can develop mutation in second one later. Lecture 20: proto-oncogenes, oncogenes + tumor suppressor genes.

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