CSB332H1 Lecture Notes - Lecture 7: Osmotic Concentration, Resting Potential, Squid Giant Axon

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When there is no net movement of ions through the plasma membrane, then it is similar to a state of the neuron called the resting membrane potential. At resting membrane potential, there is no net flow of ions. Equilibrium potential is reflective of the resting membrane potential. The resting membrane potential is not only dependent on the equilibrium potential of k+. The resting membrane potential of a typical neuron is dependent on a number of factors. There are other ions and their respective equilibrium potentials that are involved in the generation and the maintenance of the resting membrane potential. The resting membrane potential of a neuron is dependent on na+, k+, and the atpase pump. The currents that contribute to the resting membrane potential are of two entities: k+ leak current. Voltage-gated k+ channels are open when the resting membrane potential is reached: na+ leak current. Nalcn channels are the predominant na+ leak current channels.

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