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CSB332H1 Lecture Notes - Tetraodontidae, Cerebral Hemisphere, Cytoplasm

Cell and Systems Biology
Course Code
Melanie Woodin

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CSB332H1S Synapse Neurobiology L1; Jan. 9, 2012
Read Ch. 4, 5 (Neuron to Brain 5th ed.)
Know all info in text related to figures used, know all info that relates to class material
Olfactory bulb has direct connection to hippocampus
Info comes in thru sensory recs via sensory systems, certain circuits
Cognitive input thru higher centres
brain makes decision carried out thru PNS causes internal change in smooth or skeletal
In order to have act pot, need
membrane pot (needs dif in
electrical charge btwn inside &
outside of cell)
built up thru prot gradients at
Ion channels contribute to
generate membrane pots when
opened, help generate act pots
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Lipid bilayer
Ions cannot directly pass thru, must
move thru prots
Channels = membrane spanning;
don’t use ATP
When opened ion goes thru down
electrochemical gradient
Would run these gradients gown if
always open
so use transporters (ex. Na K
ATPase) to move ions against conc
grad establish ion gradient (so
when channels opened, ions can
move down grad)
Ion channel physiology field
relatively new
Physical structure of many unknown,
can predict from a.a. structure; need
to use crystalography
Standard ion channel
Span lipid membrane
<10nm in width
Packed in tightly, especially in post-synaptic density
Selectivity pocket – normally selective, used conc grad
Some allow multiple ions thru
Selectivity filter determined by a.a.s that line it
Cation can pass thru cation-selective ion channel since (-)ly
But cannot pass thru if gate closed, most open and close; some
always open
Ion channels allow passive flow
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