CSB332H1 Lecture Notes - Lecture 12: Dentate Gyrus, Pyramidal Cell, Granule Cell

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coppercattle724

11 Aug 2012

School

UTSG

Department

Cell and Systems Biology

Course

CSB332H1

Professor

Melanie Woodin

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Blue dots control, testing strength of synapse. Stimulate perforant fibres every 5min, then record from principle cell. See strength stays same so sees test stimulus doesn"t change synapse strength, so get baseline: during test stimulation, test epsp not enough to open ampar. Red dots are stimulated pathway, trying to induce plasticity at arrows: tetanic stimuli (15/s for 10 sec) to pp at arrows. Ltp: specific to input stimulated, need for learning & memory. There are other types of long-term plasticity but ltp & ltd are the 2 most studied. Need to lay down long term memories. Act pots down bundle of axons (perforant fibre pathway) onto. Pathways w bundles of axons, cell bodies in thal dendrities of principle neurons in dentate gyrus. Release glutamate ampa & nmda (excitatory synapses) Summate at cell bodies in dentate. Axons synapse onto dendrites in principal cells in ca3. Excitatory synapses, if enough then generate act pot to schaffer.

Related Questions

Changes in the interaction between neurons or neural plasticityoccur throughout the nervous system. In particular, it is believedthat synaptic plasticity in the hippocampus is critical for storingspecific types of information that are involved in thepsychological process of memory. There is extensive evidenceindicating that specific glutamate receptors atasymmetric/excitatory synapses are involves in specific aspects ofacquisition and maintenance/expression of synaptic plasticity.

Describe the roles of the NMDA and AMPA receptors in synapticplasticity within in the hippocampus. Your answer should addressthe nature of the input necessary to induce synaptic plasticity andhow each of these receptors contribute to that process, including abrief description of downstream signaling. As well as, attributesof these receptors that allow them to perform specific roles insynaptic plasticity

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Muscle Length (mm)	3.10	3.20	3.30	3.40	3.50	3.60	3.70	3.80	3.90	4.00
Passive Force (g)	0.00	0.33	0.50	0.72	0.90	1.08	1.31	1.52	1.70	1.91
Active Force (g)	0.32	0.26	0.22	0.20	0.18	0.15	0.11	0.08	0.05	0.02

Were you able to grade the strength of the contractions of the strip of cardiac muscle by varying the strength of the stimulus voltage? Briefly describe what you observed

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5. Which of the following terms means the process of rehearsing information to allow it to

move from short-term memory to long-term, permanent memory.

A. Working memory

B. Rehearsal memory

C. Transient memory

D. Consolidating memory

E. Procedural memory

6. The Skinner box best represents which type of learning?

A. Hebbian synaptic plasticity

B. Relational

C. Motor

D. Stimulus-response

7. Addiction is a type of learned behavior that involves Hebbian synaptic plasticity between

which two regions of the brain?

A. nucleus raphe magnus and thalamus

B. locus coerulus and cerebral cortex

C. pons and cerebellum

D. substantia nigra and prefrontal cortex

E. ventral tegmental area and nucleus accumbens

8. Famous short-term memory loss patient H.M. had undergone surgery for intractable

epilepsy that removed the medial aspects of __________________ bilaterally.

A. hypothalamus

B. thalamus

C. globus pallidus (of basal ganglia)

D. hippocampus (in temporal lobe)

E. prefrontal cortex

9. Brenda Milner's research and observation of patient H.M. revealed that long-term

memories are most likely **NOT** stored in _______________.

A. amygdala

B. hippocampus

C. hypothalamus

D. posteriors aspects of temporal lobe

E. cerebral cortex

10. Which one of the following memories is *not* intact for patient H.M.?

A. Memories prior to surgery

B. Non-declarative memories that are rehearsed

C. Long-term declarative memories of new facts and events

D. Procedural memory

11. Implicit memories are thought to be stored in _____________ while explicit memories are

thought to be stored in ________.

A. cerebellum; hippocampus

B. basal ganglia; hippocampus

C. cerebellum; amygdala

D. cerebellum; prefrontal cortex

E. basal ganglia; prefrontal cortex

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CSB332H1 Lecture Notes - Lecture 12: Dentate Gyrus, Pyramidal Cell, Granule Cell

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