EEB325H1 Lecture Notes - Lecture 2: Diabetes Mellitus Type 2, Pima People, Insulin Resistance
9 Feb 2017
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Eeb325 lecture 2: human evolution with modern environments. Food availability, composition > obesity, diabetes and other health related issues. Pathogens and parasites to which we are commonly exposed > allergies, asthma. Glucose converted into glycogen or fat: limited space for glycogen storage, infinite storage of fat, storing fat more efficient than storing glycogen (1 pound of fat converts to same energy at 2 pounds of glycogen) Pancrease releases insulin which signals body to store glucose as glycogen. I(cid:374) type ii dia(cid:271)etes, a(cid:374) i(cid:374)di(cid:448)idual"s (cid:271)ody (cid:271)e(cid:272)o(cid:373)es u(cid:374)respo(cid:374)si(cid:448)e to i(cid:374)suli(cid:374)- insulin resistance so no storage of glucose as glycogen: high blood glucose. Mexico pima- traditional lifestyles, grow their own food, harvest etc: low prevalence of type ii diabetes (still higher than other mexicans) Us pima is desert lands- us diverted water resources away and so these people forced to have high fat, highly refined government diet. The little farming done was mostly mechanic: high prevalence of type ii diabetes.
