EHJ352H1 Lecture Notes - Lecture 18: Intermediate Frequency, Neutral Mutation, Mutation Rate

75 views3 pages

Document Summary

Lecture 18: questions about the genomics of adaptation. What fraction of the differences between humans and chimps are adaptive, deleterious and neutral. Basic patterns of human diversity consistent with strong effects of history and weak purifying selection on human genome. Where is the signal for adaptation aka positive selection: evidence for adaptive protein evolution: Ka/ks >1 provides evidence for adaptive evolution, however this type of positive selection genome wide is rare. However ka/ks <1 could still mean that positive selection is acting in parts of the gene. Polymorphisms within species and divergence between species to test for adaptive evolution. There is some fixed differences between species since coalescence and polymorphisms within species: kimura neutral theory revised: Uo= neutral mutation rate, t is the time. Thus the rate of molecular evolution will be 2uot for two genes. Uo=fout, where fo is the fraction of sites that are neutral, and ut is the total mutation rate.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents

Related Questions