EEB325H1 Lecture Notes - Lecture 1: Fitness Landscape, Felis, Acinonyx
18 Jan 2018
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Lecture 1 | intro & vulnerability: diagnostics. The questions medicine asks are all proximate questions. Diseases need both proximate explanations of underlying mechanisms as well as ultimate explanations of why any vulnerabilities exist. Where did a given infectious disease originate: t(cid:396)eat(cid:373)e(cid:374)t. Ability(cid:9)to(cid:9)invade(cid:9)a(cid:9)host,(cid:9)exploit(cid:9)host(cid:9) tissues,(cid:9)transmit(cid:9)to(cid:9)new(cid:9)hosts;(cid:9) maintaining(cid:9)those(cid:9)abilities(cid:9)in(cid:9)the(cid:9) face(cid:9)of(cid:9)interventions(cid:9) evolution has shaped our resistance to diseases and responses to diseases. Selection is slow: mismatch with modern environments. In environment in which turtles evolve, hard shells provide as predator defense. However, 200 million years ago not a lot of cars, which are big threat to turtles now. T(cid:396)ait e(cid:448)ol(cid:448)ed i(cid:374) past e(cid:374)(cid:448)i(cid:396)o(cid:374)(cid:373)e(cid:374)t is(cid:374)"t as useful i(cid:374) (cid:272)u(cid:396)(cid:396)e(cid:374)t e(cid:374)(cid:448)i(cid:396)o(cid:374)(cid:373)e(cid:374)t. Early(cid:9) agricultural(cid:9) revolution(cid:9) (cid:9) d e r e v o c s i (cid:9)d n i l l i c i n e. First(cid:9)appearance(cid:9) of(cid:9)homo(cid:9)sapiens(cid:9) in(cid:9)fossil(cid:9)record(cid:9) l l (cid:9) n o i t u o v e (cid:9)r a r u t l u c i r g (cid:9)a y l r a.
