EEB325H1 Lecture Notes - Lecture 2: Innate Immune System, Rhinovirus, Clinical Trial

• School: UTSG
• Department: Ecology & Evolutionary Biology
• Course: EEB325H1
• Professor: Nicole Mideo

Document Summary

Lecture 2 | human evolution & host defense. A refresher on fever from bio220: ele(cid:448)ated (cid:271)od(cid:455) te(cid:373)pe(cid:396)atu(cid:396)e is a (cid:272)o(cid:373)(cid:373)o(cid:374) (cid:396)espo(cid:374)se to i(cid:374)fe(cid:272)tio(cid:374)s. Two possible evolutionary explanations for fever: fever is a direct effect of a pathogen replicating in a host. Fever is predicted to increase with pathogen success. Disease: fever is a response of the host to the pathogen. Fever is predicted to decrease pathogen success (and benefit the host). Beha(cid:448)iou(cid:396)al (cid:858)fe(cid:448)e(cid:396)(cid:859) i(cid:374) dese(cid:396)t iguanas: igua(cid:374)as a(cid:396)e e(cid:272)tothe(cid:396)(cid:373)s, a(cid:374)d the(cid:396)efo(cid:396)e (cid:271)eha(cid:448)iou(cid:396)all(cid:455) (cid:396)egulate thei(cid:396) (cid:271)od(cid:455) te(cid:373)pe(cid:396)atu(cid:396)es, igua(cid:374)as i(cid:374)je(cid:272)ted (cid:449)ith li(cid:448)e (cid:894)o(cid:396) dead(cid:895) (cid:271)a(cid:272)te(cid:396)ia te(cid:374)d to (cid:271)ask a(cid:374)d ele(cid:448)ate thei(cid:396) (cid:271)od(cid:455) te(cid:373)pe(cid:396)atu(cid:396)es. *(cid:9) (cid:9) symptoms worse in the individuals who were given anti-fever drugs! Immune response is suppressed in individuals given anti-fever drugs. (cid:449)he(cid:374) gi(cid:448)e(cid:374) t(cid:396)eat(cid:373)e(cid:374)t fo(cid:396) fe(cid:448)e(cid:396), (cid:455)ou(cid:859)(cid:396)e less a(cid:271)le to a(cid:373)ou(cid:374)t st(cid:396)o(cid:374)g i(cid:373)(cid:373)u(cid:374)e (cid:396)espo(cid:374)se f(cid:396)o(cid:373) a(cid:374) infection. Our immune response has evolved to work best at higher temperatures.