FRE272H1 Lecture : Chapter 1-3
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Chose the correct answers on one through 15(plese help)
1.A research group hypothesizes that successful infection by HIVdepends upon the expression of FSH3, a human gene. They overexpressthis gene in T cells (Which HIV normally infects) so that FSH3protein levels are very high in these cells. In other T-cells, theymutate FSH3 so that none of its encoded protein is made. They thenmeasure HIV infection rate in the control, overexpression, andmutant T cells. The three cultures are otherwise grown in the sameway.
What is the independent variable(s) in this experiment? (Selectall correct answers)
FSH3 protein levels | ||
The medium in which cells are grown | ||
The temperature at which cells are grown | ||
HIV resistance of cells |
Question 2
Which arises from an error in a measurement or observation?
Technical variability | ||
Biological variability | ||
Standard error | ||
Standard deviation |
Question 3
Use the following description of an experiment to answer thenext question.
A research group hypothesizes that successful infection by HIVdepends upon the expression of FSH3, a human gene. They overexpressthis gene in T cells (Which HIV normally infects) so that FSH3protein levels are very high in these cells. In other T-cells, theymutate FSH3 so that none of its encoded protein is made. They thenmeasure HIV infection rate in the control, overexpression, andmutant T cells. The three cultures are otherwise grown in the sameway.
What is the control group(s) in this experiment? (Select allcorrect answers)
The unaltered T cells | ||
The medium in which cells are grown | ||
The T cells in which FSH3 is mutated | ||
The T cells overexpressing FSH3 |
Question 4
How many of the following statements are true?
I. All papers have an abstract, methods, results, and discussionsection
II. The methods always follows the introduction
0 | ||
2 | ||
1 |
Question 5
If scientific convention states that when a P value of less than0.05 is considered significant (in other words, the two groupsbeing measured are actually different), this means that: (Selectall correct answers)
If you were to repeat the experiment 100 times, there would notbe a significant difference between the groups in 5 of theexperiments | ||
95% of all conclusions that state two groups are not differentbased on a 0.5% p-value threshold are false negatives | ||
The groups are actually not different from each other 95% of thetime | ||
5% of all conclusions that state two groups are different basedon a 0.5% p-value threshold are false positives |
What information is typically found in the introduction sectionof a paper? (Select all that apply)
The dependent and independent variables within the study | ||
Which areas of the field are not well understood and whatquestion the study addresses | ||
How the main question of the paper is related to other researchin the field. | ||
How previous work forms the basis for the current study | ||
The purpose of the study | ||
Details of the approaches used | ||
A summary of relevant related studies |
Question 7
How can you judge for yourself whether the conclusions reachedin a paper are valid? (Select all that apply)
Read papers of other authors studying the same question or areaof inquiry | ||
Determine if each hypothesis is supported by different types ofevidence/approaches. | ||
Consider closely whether the data actually both addresses andsupports the authorâs hypothesis. | ||
Examine the amount of data in the paper, and how long the paperis. | ||
Whether the authors find a mechanism, or exactly how on variableaffects another. | ||
Interpret the data for yourself without looking the discussion,then compare your interpretations to that of the authorâs. |
Question 8
Where can you usually find the institutional affiliations (wherethey work) of the authors?
Within the discussion | ||
In the acknowledgements section | ||
Below the authors list | ||
This is not usually included in papers |
Question 9
Other than publishing primary research articles, what is themain way scientists disseminate their results?
Lab meetings | ||
Personal correspondence | ||
Conference seminars | ||
Public lectures |
Question 10
Use the following description of an experiment to answer thenext question.
A research group hypothesizes that successful infection by HIVdepends upon the expression of FSH3, a human gene. They overexpressthis gene in T cells (Which HIV normally infects) so that FSH3protein levels are very high in these cells. In other T-cells, theymutate FSH3 so that none of its encoded protein is made. They thenmeasure HIV infection rate in the control, overexpression, andmutant T cells. The three cultures are otherwise grown in the sameway.
What is the experimental group(s) in this experiment? (Selectall correct answers)
Each group is its own control | ||
The T cells overexpressing FSH3 | ||
The T cells in which FSH3 is mutated | ||
The unaltered T cells |
