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GER150H1 Lecture : 8th Feb 2012 TUT 5.doc

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School
UTSG
Department
German
Course
GER150H1
Professor
Lehleiter

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Document Summary

Who is the patient (a description: a young man. Doctor discovers the wound (because the sister flaps a bloody handkerchief) The horses break their reins and sort of talk". The doctor narrates the story feels that they expect so much from him he is making the ultimate sacrifice by sacrificing rosa feels like he"s being taken advantage of everything he does, he is doing his duty as doctor. 2 things that confront him: leaving rosa, discovers the wound. At position of authority but at the same time has no power. As much as he puts out for society he is. Responsibilities of a god but not the actual powers of a god. Wound was like a rose, like a flower. My horse died, great, now i have 2 horses. Main characters: marie, woyzeck, doctor, captain, the drum- major, andre. Woyzeck and marie were not married, but had a child. Examines the social relationships in a hierarchical and class based society.

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Related Questions

One medical practice that has been widely discussed in recent years involves defensive medicine, in which a doctor orders more medical tests and X-rays than she or he might have in the past—not because of the complexity of the case, but because the doctor fears being sued by the patient for medical malpractice. The extra tests may establish that the doctor did everything reasonable and prudent to diagnose and treat the patient.

What does this tell you about the burden of risk?

What impact does this burden place on you and your family in your everyday life?

Is the doctor wrong to do this, or is it a necessary precaution?

Is there some way to change this situation?

One of your colleagues, Margaret, tells you about her medical situation one day in the lab. She states that she recently went to the doctor because she has been gaining substantial amounts of weight and she can’t figure out why. She also feels like she never has enough energy (severe exhaustion). She has tried to lose the weight by exercising, but claims that her “muscles hurt” every time she tries to do so. Her doctor runs some tests and determines that Margaret has a mutation in isocitrate dehydrogenase, which is an enzyme that functions in the citric acid cycle. This mutation results in a non-functional enzyme, and as a result, the citric acid cycle functions at a very low rate.

Margaret then tells the doctor that she really wants to lose weight, and as heard of a compound called dinitrophenol (DNP). The doctor then explains to Margaret that DNP is extremely unsafe. He explains that the compound has been found to cause some patients to become very sick and die. He tries to explain that DNP uncouples the chemiosmotic machinery by making the lipid bilayer of the inner mitochondrial membrane leaky to H+. How exactly does DNP affect the body? What is it doing? What metabolic fucntions are being affected by this compound?

Given the scenario/situation, respond to all questions with complete sentences.

One of your colleagues, Margaret, tells you about her medical situation one day in the lab. She states that she recently went to the doctor because she has been gaining substantial amounts of weight and she can’t figure out why. She also feels like she never has enough energy (severe exhaustion). She has tried to lose the weight by exercising, but claims that her “muscles hurt” every time she tries to do so. Her doctor runs some tests and determines that Margaret has a mutation in isocitrate dehydrogenase, which is an enzyme that functions in the citric acid cycle. This mutation results in a non-functional enzyme, and as a result, the citric acid cycle functions at a very low rate.

a) Using your knowledge of cellular respiration, explain why Margaret is showing the following symptoms: weight gain (why is she storing fat instead of burning it), severe exhaustion, and muscle pain when she exercises.

Margaret then tells the doctor that she really wants to lose weight, and as heard of a compound called dinitrophenol (DNP). The doctor then explains to Margaret that DNP is extremely unsafe. He explains that the compound has been found to cause some patients to become very sick and die. He tries to explain that DNP uncouples the chemiosmotic machinery by making the lipid bilayer of the inner mitochondrial membrane leaky to H+.

b) Explain how the effects on the chemiosmosis could cause weight loss and death.

c) How would you describe DNP works using the second law of thermodynamics?

d) What type of reaction does DNP create and draw a graph of the free energy changes of that reaction?

e) Come up with an alternative, safer treatments for Margaret’s condition. Explain how it would work.