Rise of europe as a result of long-distance trade and crusades almost collapsed by the mid-16 th century. Italian economic power was driven by italian monopoly on byzantine trade with constantinople. In 1453, constantinople fell to the turks under mohammed ii (1451-1481) and ended the. Byzantine empire: trade with the east vanished, inability to stop the turks seemed desperate for the europeans. Mohammed ii grew the ottoman empire into the greatest state in the world. All of eastern europe was under ottoman control. Turks wanted to control to the adriatic and turn italy into another ottoman province. In 1514, ottomans took over persia and syria/egypt in 1516 & 1517. Ottomans tripled their territory by 1559 most powerful state in the world in terms of central organization. Turks used their balkan power base to launch sophisticated invasions battle of mohacs (1526) near hungary slaughtered the christian army and annihilated christian forces backed by the.