HMB200H1 Lecture Notes - Pharmacogenetics, Endorphins, Positron
Document Summary
20th century neuroscience: synapses and neurons. People began stimulating circuits what is inside the cns and whole nerves that produce these responses. Sherrington, cajal and pavlov: from reflexes to synapses, from circuits to learning (1880- 1920) From electrical to molecular models (ions, transmitters, proteins) Genes and cognition concept of synapse as functional connection between spinal neurons. First, sherrington proposed that there is something else happening inside the spinal cord. Mapped spinal reflexes, monosynaptic, disynaptic, and multisynaptic. ~1ms synapses are excitatory or inhibitory, and have a delay of integrative actions of spinal cord near synapses. Golgi"s method: used silver, and by putting silver into the tissue, some of it was concentrated inside single neurons. Got pictures of clumps that look like real neurons. Hard to see and separate neurons are all overlapping. Only 1- 2% of neurons take up the silver (can see separate neurons using golgi"s silver method) Cajal worked on this method and improved it.
