HMB200H1 Lecture : Sleep Disorders & Retina

26 views3 pages
10 Feb 2012
School
Department
Course
Professor

Document Summary

Slow feedback pathways ants, flies, all vertebrates, humans. All cells have own rhythm, damped oscillation if. Scn maintains rhythm, more stably rhythmic, not restored by input (gradually disappears) molecular clock descending signals to parts of body to coordinate rhythms. Ex. to pineal gland in birds, heart, liver. Clock + cycle dimerize turn on expression. Dimerization of per & cry in mammals of cry & tim (+) feedback activates clock (-) feedback: gene transcription prot dimerization feedback. Found in fruit flies caseine kinase controlling. Photic influence mammals from retina (melanopsin- containing ganglion cells) Can still respond in absence of rods and cones. Release glutamate into scn glutamate double time modulator of (-) feedback loop (do help) controls photic influence into scn fixes cycle: within scn all cells fire rhymically since slow rhythm) Mostly tiny gaba cells (don"t need fast cells. O/h neurons found to be missing in affected. Like discovery of dop: unstanding of melanopsin changed understanding of patients retinal development.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Questions