HMB200H1 Lecture Notes - Lecture 17: Reticular Formation, Orbitofrontal Cortex, Hand Washing
Document Summary
Fear learning seems to occur in lateral & basal lateral amygala, then descending paths to hypothal & brainstem. Fear experiences influenced by context, surrounding circumstances, info from hippocampus. Fear very much dependent on activation of amygdala. Fear activated by nmda or cckb agonists in amygdala: nmda glutamate rec activation for turning on fear, cck as a peptide makes panic attack in humans blocking blocks panic attacks but not endogenous panic attacks blockers. Stress/anxiety activated by crh in bnst: corticotropin releasing hormone, also produced in amygdala goes to recs in extended amygdala. Rats) panic-like effects: prevent systemic & amygdala effects of cck by using cckb rec. Ptsd: work on learning of fear within amygdala circuits. Post-traumatic stress (used to be called shell shock): Fear brought on by specific trauma, e. g. , violence or accident. Nightmares: very often in ppl w near-death experiences, violent attacks, accidents longterm pts.