HMB200H1 Lecture Notes - Voltage Clamp, Patch Clamp

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Published on 23 Sep 2012
School
UTSG
Department
Human Biology
Course
HMB200H1
Professor
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Neurophysiology review:!
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- Voltage clamp method: (patch clamp uses this method as a basis) usage of an electrode to keep the voltage constant and measure the current I so
that when membrane voltage is manipulated the voltage injected represents the membrane voltage!
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- terminals of the presynaptic neurons connect to dendrites or dendritic spines when too crowded on the dendrites (ineffective integration of
PSPs) usage of spines equal access to dendrite shaft!
plasticity of the spine (can change shape)!
- synapse makes integration leakier due to loss of distal signals BUT allows for a lot of input!