HMB202H1 Lecture Notes - Lecture 4: Animal Magnetism, Clinical Trial, Antoine Lavoisier
Document Summary
Neurobiology of placebo effects: hedge"s g is a statistical measure of effect size (efficacy) where the graph shows response value with use in all drugs due to placebo effect (how mind influences body). Increase placebo response in new anti-depressants" trials: placebo effect was shown to be effects of the imagination by franklin and lavoisier using animal magnetism to induce healing effects. Effects were real but there was no animal magnetism. Placebo is the gold standard which is very powerful. 1st clinical drug trial with double-blinded and placebo-controlled setting showed placebo just as effective as actual drug (morphine) Placebo works best against analgesia/pain, psychiatric disorders and parkinson"s disease but not against degenerative bone disease nor cancer etc. : expectancy mediates placebo as patients believe and condition themselves behaviourally via patient-physician interaction. Experiment: pain reduction rank using visual analogue skill (vas: opioids and non-opioids were used with and without doctor administering to treat pain.
