HMB265H1 Lecture Notes - Lecture 3: Ovarian Cancer, Amylopectin, Genetic Testing

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HMB265H1 Full Course Notes
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HMB265H1 Full Course Notes
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25 documents

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Hmb265: human and general genetics lecture #3. Molecular basis of genetic polymorphisms and their detection. Detection of genetic polymorphisms: snps snp detection using pcr, dna sequencing, new technologies. Reading: hartwell et al. , 1st can. edition, chapter 2 (emphasis on pages 22-23); chapter 7 (emphasis on pages 215-219); chapter 8 (emphasis on pages 236-239); chapter 15 (emphasis on pages 491-500) Allele = variant at a genetic locus: mendel called them factors . Mutation is the process whereby genes change from one allelic form to another: the creation of entirely new alleles can occur. Genes mutate randomly, at any time and in any cell of an organism. Can arise spontaneously during normal replication, or can be induced by a mutagen: mutagen can be chemical substance, x-ray, etc. Only mutations in germline cells can be transmitted to progeny (subsequent generation: somatic mutations can not be transmitted. Inherited mutations appear as alleles in populations of individuals.

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