HMB265H1 Lecture Notes - Lecture 5: F1 Hybrid, Mendelian Inheritance, Red Blood Cell

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HMB265H1 Full Course Notes
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HMB265H1 Full Course Notes
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Hmb265: lecture 5 - extensions of mendelian genetics part 1 (sept. 22) Question: sheldon"s father and amy"s brother suffer from a rare autosomal recessive disease. Sheldon"s father has to be homozygous recessive. Chance that sheldon is carrier is 100% (father has 2 recessive alleles, has to pass one of them to all children) So sheldon is a carrier (chance that s passes his allele to son = ) If she"s a carrier, chance that a passes on to her child = . Chance that amy is carrier is (cid:1152) Chance of not having the disease is: 1-(cid:6820) = (cid:6821) This is the chance of having the disease. Individuals with a rare metabolic disorder are indicated by shaded symbols. What are the genotypes of individuals ii-3 and ii-4. Ii-3 has the disease so has to homozygous recessive. Ii-4 has son with disease so must be carrier aa. Different mutations have different effects on phenotype.

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