HMB265H1 Lecture Notes - Lecture 3: Ovarian Cancer, Mutation Rate, Product Rule

• School: UTSG
• Department: Human Biology
• Course: HMB265H1
• Professor: Maria Papaconstantinou

Document Summary

Lecture 3 molecular basis of genetic polymorphisms and their detection. Lecture 3 outline: from mendel"s traits to genes, genetic variation and phenotype, detection of genetic polymorphisms, snps, snp detection using pcr, dna sequencing, new technologies. It can arise spontaneously during dna replication, or induced by a mutagen: however, mutations only in germ-line cells (cells that divide to produce mature gametes) can be transmitted to progeny mutations in somatic cells are not inherited. Inherited mutations appear as alleles in populations of individuals. Germline and somatic mutations: only germline mutations are inherited from one generation to the next, somatic mutations are not. General observations of mutation rates: mutations affecting phenotype occur very rarely, different genes mutate at different rates, mutation rate varies from 1 in 1,000 to 1 in. Classification of mutations by effect on dna molecule. Chromosomal rearrangements: affect many genes at one time: deletions, insertions, inversions, and translocations can occur to more than one gene at the same time.