HMB265H1 Lecture Notes - Lecture 14: Statistical Power, Frequency Distribution, Backcrossing
31 Jan 2018
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HMB265H1 Full Course Notes
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There are examples of simple mendelian traits in humans e. g. , cf, hd, sickle- cell anemia, etc: most attributes follow the patterns of complex trait inheritance with a continuous distribution. Dissection of quantitative traits: qtl: quantitative trait loci (qtl): loci that influence quantitative traits, a quantitative effect can be attributed to 2 or more important genes. Identify by using genetic markers molecular markers like snps because we know exactly where they are on the chromosome: heavily rely on statistical methods. Step 1: make an informative cross between individuals that are inbred relative to each other, and which differ. Step 2: determine the frequency distribution in the f2: once we have this, we can take each category of fruit and assay the dna for molecular markers. Step 3: use molecular markers to genotype the individuals, attempting to find markers that co-segregate with the trait: most loci will show this type of segregation pattern.
