HMB265H1 Lecture Notes - Lecture 4: Melanin, Albinism, Consanguinity
Lecture 4: Mendelian Traits in Humans & Human Pedigree Analysis
Mendelian inheritance and humans: same principles apply
• Albinism: autosomal recessive condition
o Two copies of A produce Tyrosine enzyme → melanin
▪ Aa is also sufficient to produce melanin
▪ aa no tyrosine → albino
Autosomal Inheritance
• Human autosomal traits are located on the non-sex chromosomes (1-22)
• They may be inherited as:
o Autosomal dominant
o Autosomal recessive
• Homozygous dominant and heterozygotes exhibit the
affected phenotype
• Males and females are equally affected and may
transmit the trait
• Affected phenotype does not skip a generation
Autosomal Recessive
• Only homozygous recessive individuals exhibit the affected phenotype
• Males and females are equally affected and may transmit the trait
• May skip generations
• 2 recessive alleles are needed for the phenotype to be expressed
Pedigrees
• Cannot do controlled breeding experiments on humans, use model organisms and human
pedigrees to dissect Mendelian traits of interest
o Humans have a very long generation time
• Pedigrees are an orderly diagram of a family’s relevant genetic features extending through multiple generations
• Pedigrees help us infer it a trait is from a single gene and if the trait is dominant or recessive, autosomal or sex-
linked
Dominant Traits
• Affected children always have at least one affected parent
• As a result, dominant traits show a vertical pattern of inheritance: the trait shows up in every generation
• Two affected parents can produce unaffected children, if both parents are heterozygotes
• Vertical pattern of inheritance in pedigrees
o Affected individual in every generation
Recessive Traits
• Affected individuals can be the children of two unaffected carriers, particularly as the result of consanguineous
matings
• All the children of two affected parents should be affected
• Rare recessive traits show a horizontal pattern of inheritance: the trait first appears among several members of one
generation and is not seen in earlier generations
• Recessive traits may show a vertical pattern of inheritance if the trait is extremely common in the population
• Most traits are recessive
• Dominant deleterious traits do not continue to manifest
• Gene load→lethal recessive alleles
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