HMB265H1 Lecture Notes - Lecture 18: Homologous Chromosome, Haploinsufficiency, Phenotype
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HMB265H1 Full Course Notes
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Document Summary
Gene imbalance in del heterozygotes, might result in haploinsufficiency. Deletion loops: unpaired bulge of normal chromosome that corresponds to an area deleted from a paired homologue(genes or regulatory dna that are similar in different species because of descent from a common ancestral species) no recombination can occur. Pseudodominance: appearance of a recessive phenotype in a heterozygote containing the recessive gene on one chromosome and a deletion or only part of the dominant gene on the corresponding part of the homologous chromosome. Deletions can be used to locate genes map. Complementation(phenomenon by which the effects of two different nonallelic mutations in a gene are partly or entirely canceled out when they occur together. Or. production of normal phenotype in an individual heterozygous for two closely related mutations with one on each homologous chromosome and at a slightly different position): deletion mapping. Genes may be placed in a new location that modifies their expression.
