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13 Jan 2011
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LECTURE 01: Introduction
Information about tutorial group will be posted at the end of the week on PORTAL
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18 – genetics hugely relevant to the real world
Genetics applied to everyday life constantly
Also underlying various aspects of biology
19 – Genetics asks these questions
20 – medical genetics a growing field
Genetic basis
Resistance to HIV, malaria have a genetic component
Disease not purely environmental
Genetic basis: genetic cause of a disease
Mutation at DNA level
21 – human chromosomes
Different human traits mapped onto chromosomes – variation at each site
How variation is inf luencing different traits
22 – mutations at each chromosomes that effect chances of getting specific diseases
Variation at DNA level influence variation in these traits
23 – 1) ex. diabetes complex
Much promise for these goals
4) individuals vary in drug response
24 – assess risk, advise test, interpret results, etc.
25 – private sector component
27 – what is truly a disease and what is natural variation?
28 – bigger and better crops to improve food supply
30 – inheritable component, DNA, encodes proteins, which affect traits
31 – cannot read genome to determine personality
Must avoid genetic determinism
32 – become sceptical about genetics claims
33 – arrows indicate in human chromosomes regions where genes identified individuals chance of getting
type 2 diabetes
Mutations?
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Document Summary

Information about tutorial group will be posted at the end of the week on portal. 18 genetics hugely relevant to the real world. Resistance to hiv, malaria have a genetic component. Different human traits mapped onto chromosomes variation at each site. 22 mutations at each chromosomes that effect chances of getting specific diseases. Variation at dna level influence variation in these traits. Much promise for these goals: individuals vary in drug response. 24 assess risk, advise test, interpret results, etc. 28 bigger and better crops to improve food supply. 30 inheritable component, dna, encodes proteins, which affect traits. 31 cannot read genome to determine personality. 33 arrows indicate in human chromosomes regions where genes identified individual"s chance of getting type 2 diabetes. 34- diet and lifestyle thus diabetes on the rise environmental effects. Mutations increase by a bit, while environmental effects have massive impact, the major impact. 36 sliding scale from genetic to environmental effects.

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