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Lecture

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6 Pages
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Department
Human Biology
Course Code
HMB265H1
Professor
Stephen Wright

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Gene A ½ Aa
Gene B ¾ resemble phenotypically
Gene C ½
Gene D all
Gene E ¾
So, multiply all five fractions 9/64
If the question asked will NOT phenotypically resemble the female parent? 1- 9/64 so
55/64
Resembling the male parent none will resemble the male parent phenotypically
LECTURE 03: molecular basis of genetic polymorphisms and their detection
Mendels laws of segregation from POV of present knowledge
DNA level
Mendel was looking at variation encoded at DNA level ultimately effecting protein level,
then affecting traits
Allelic differences can impact any part of the pathway
Mendel looked at phenotypic variation
SNPs single difference in DNA
Follow Mendels laws but no dominant or recessive allele at DNA because this is
the genotypic level (one exception)
GT heterozygote
Allelic variation generated by
Point mutations single change in DNA
Insertions/deletions
Changes in repeat number
Chromosomal rearrangements
Allelic variation that may end up leading to phenotypic variation
From POV of molecular biology
Gene ultimately leads into protein, which functions or confers a trait
Amino acid replacement mutation change in protein folded different, functioning
differently
Mutation in promoter region that blocks RNA transcription no protein effect on
phenotype
Figure 2-15: all possible spots that could lead to novel allele
Null alleles knock out function
Wild type normal
Intron if at splice site, protein structure may change but can also be null
No effect on phenotype
www.notesolution.com
oDNA level can have polymorphisms that do nor dont effect phenotype
www.notesolution.com

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Description
Gene A Aa Gene B resemble phenotypically Gene C Gene D all Gene E So, multiply all five fractions 964 If the question asked will NOT phenotypically resemble the female parent? 1- 964 so 5564 Resembling the male parent none will resemble the male parent phenotypically LECTURE 03: molecular basis of genetic polymorphisms and their detection Mendels laws of segregation from POV of present knowledge DNA level Mendel was looking at variation encoded at DNA level ultimately effecting protein level, then affecting traits Allelic differences can impact any part of the pathway Mendel looked at phenotypic variation SNPs single difference in DNA Follow Mendels laws but no dominant or recessive allele at DNA because this is the genotypic level (one exception) GT heterozygote Allelic variation generated by Point mutations single change in DNA Insertionsdeletions Changes in repeat number Chromosomal rearrangements Allelic variation that may end up leading to phenotypic variation From POV of molecular biology Gene ultimately leads into protein, which functions or confers a trait Amino acid replacement mutation change in protein folded different, functioning differently Mutation in promoter region that blocks RNA transcription no protein effect on phenotype Figure 2-15: all possible spots that could lead to novel allele Null alleles knock out function Wild type normal Intron if at splice site, protein structure may change but can also be null No effect on phenotype www.notesolution.com
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