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HMB265H1 (300)
Lecture

Notes taken during lecture


Department
Human Biology
Course Code
HMB265H1
Professor
Stephen Wright

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LECTURE 11: Feb.15/2011
Huntingtons disease once one generation doesnt have it, the disease is eliminated in the
FAMILY
Also genetics, ethical issues
Need to find where it is, before they can do anything about it
Look at molecular markers and their segregation
Find patterns of inheritance, and move from genetics to molecular studies and biochemistry
Took decades TO FIND THE GENE AND HOW IT WORKS TO FIND A CUREhow do
you isolate The gene of interest using genetic tools
Impetus to study genomes
Human genome main funding incurred by medical implications
Having genetics pave a road map makes the process faster
Two different funding one public, one privately funded
Two different approaches
Collins hierarchical approaches sequence clones after having ordered them
Venter whole genome dive right in
Cannot read sequence of chromosome from start to finish ***
oCut copies of genome
oUsing overlapping areas to put the fragments together
Cant get any further because many sequence of repetition
oNot sure of true overlap
Want to annotate the genome to figure out whats what
oUse computational predictions as to where genes are
oUse additional evidence ie. RNA evidence
oOnce have raw sequence, then predict locations of genes, compare genes in
other species, to determine gene function
oLink up phenotypic variation to the DNA level
oWhat are the actual regions causing disease, and how can the disease be
treated?
With HD, had no idea of gene and where it was
Use segregation of phenotype and molecular markers to help
Do linkage mapping of molecular markers and relate it to phenotypes
Ultimately, to localize the gene in the genome
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