Class Notes (920,947)
CA (542,408)
UTSG (45,870)
HMB265H1 (253)
Lecture

Notes taken during lecture

4 Pages
127 Views

Department
Human Biology
Course Code
HMB265H1
Professor
Stephen Wright

This preview shows page 1. Sign up to view the full 4 pages of the document.
LECTURE 11: Feb.15/2011
Huntingtons disease once one generation doesnt have it, the disease is eliminated in the
FAMILY
Also genetics, ethical issues
Need to find where it is, before they can do anything about it
Look at molecular markers and their segregation
Find patterns of inheritance, and move from genetics to molecular studies and biochemistry
Took decades TO FIND THE GENE AND HOW IT WORKS TO FIND A CUREhow do
you isolate The gene of interest using genetic tools
Impetus to study genomes
Human genome main funding incurred by medical implications
Having genetics pave a road map makes the process faster
Two different funding one public, one privately funded
Two different approaches
Collins hierarchical approaches sequence clones after having ordered them
Venter whole genome dive right in
Cannot read sequence of chromosome from start to finish ***
oCut copies of genome
oUsing overlapping areas to put the fragments together
Cant get any further because many sequence of repetition
oNot sure of true overlap
Want to annotate the genome to figure out whats what
oUse computational predictions as to where genes are
oUse additional evidence ie. RNA evidence
oOnce have raw sequence, then predict locations of genes, compare genes in
other species, to determine gene function
oLink up phenotypic variation to the DNA level
oWhat are the actual regions causing disease, and how can the disease be
treated?
With HD, had no idea of gene and where it was
Use segregation of phenotype and molecular markers to help
Do linkage mapping of molecular markers and relate it to phenotypes
Ultimately, to localize the gene in the genome
www.notesolution.com

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.

Leah — University of Toronto

OneClass has been such a huge help in my studies at UofT especially since I am a transfer student. OneClass is the study buddy I never had before and definitely gives me the extra push to get from a B to an A!

Leah — University of Toronto
Saarim — University of Michigan

Balancing social life With academics can be difficult, that is why I'm so glad that OneClass is out there where I can find the top notes for all of my classes. Now I can be the all-star student I want to be.

Saarim — University of Michigan
Jenna — University of Wisconsin

As a college student living on a college budget, I love how easy it is to earn gift cards just by submitting my notes.

Jenna — University of Wisconsin
Anne — University of California

OneClass has allowed me to catch up with my most difficult course! #lifesaver

Anne — University of California
Description
LECTURE 11: Feb.152011 Huntingtons disease once one generation doesnt have it, the disease is eliminated in the FAMILY Also genetics, ethical issues Need to find where it is, before they can do anything about it Look at molecular markers and their segregation Find patterns of inheritance, and move from genetics to molecular studies and biochemistry Took decades TO FIND THE GENE AND HOW IT WORKS TO FIND A CUREhow do you isolate The gene of interest using genetic tools Impetus to study genomes Human genome main funding incurred by medical implications Having genetics pave a road map makes the process faster Two different funding one public, one privately funded Two different approaches Collins hierarchical approaches sequence clones after having ordered them Venter whole genome dive right in Cannot read sequence of chromosome from start to finish *** o Cut copies of genome o Using overlapping areas to put the fragments together Cant get any further because many sequence of repetition o Not sure of true overlap Want to annotate the genome to figure out whats what o Use computational predictions as to where genes are o Use additional evidence ie. RNA evidence o Once have raw sequence, then predict locations of genes, compare genes in other species, to determine gene function o Link up phenotypic variation to the DNA level o What are the actual regions causing disease, and how can the disease be treated? With HD, had no idea of gene and where it was Use segregation of phenotype and molecular markers to help Do linkage mapping of molecular markers and relate it to phenotypes Ultimately, to localize the gene in the genome www.notesolution.com
More Less
Unlock Document


Only page 1 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


OR

Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit