HMB300H1 Lecture Notes - Lecture 6: Cell Culture, Thymidine, Astrocyte
Document Summary
Neurogenesis - nt: evidence that nt are important, but they are not the driving force of depression, experiment: patch of hair on mice, hair follicles have died due to radiation directed at the hippocampus (sgz) This, in turn reduces some of the structural effects of major depression. Pi3kinase, phospholipasecg: mitogen activated protein kinase(mapk): cause different genes to be turn on, and will target creb and. Fos: pi3kinase pathway: inhibits apoptosis of neurons, phospholipasecg: increase intracellular levels of ca2, when you turn on both the mapk pathway and phospholipase c pathway you activate neoritogenesis. Stress: stress and anti-depressants have opposing effects on 2 things, neurogenesis in the sgz of the dentate gyrus, production of vegf and bdnf in the cortex and hippocampus, vegf increases proliferation in sgz. Bdnf increases neuronal survival: we know that all these neurotrophin increases neurogenesis and increase spines, more synapses etc.
