HMB300H1 Lecture 4: Lecture 4- Stress, UofT and Memory.pdf

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11 Feb 2015
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Lecture 4: stress, uoft and memory. Not all synapses in hippocampus gets strengthened. Used a model of animal learning inhibitory avoidance (passive avoidance) There are 2 chambers an upper lighted chamber and a darker one (rats like dark places) A simple form of learning (experience driven) that results in memories being formed. As the animal learns, the 831 serine residue is phosphorylated. If you want ltp to occur, you need phosphorylation of the glur1 subunit on serine 831. If 831 is phosphorylated, it is likely ltp is occurring. Also need nmdar activation in hippocampus for ltp (exception: ca3 synapse) Cpp, apv and mk801 blocks nmdars. If you block nmdars while they"re learning = block learning = blocks phosphorylation in ampa receptor = blocks ltp. Mark bear had shown that the substrate for learning was. Glua1 phosphorylated on serine 831: showed that it was nmdar dependent, as learning occurred, total levels of glur1 and. Glur2 increased, but nmdar stayed the same.

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