HMB300H1 Lecture Notes - Lecture 2: Magnetic Resonance Imaging, Diffusion Mri, Dynactin
Document Summary
Hmb300: lecture 2 memories, recall and issues. In the presynaptic (en-passant) type of synapses there are microtubules (which are also present in the dendrite of the postsynaptic cell: there is a railway system of microtubules into the synapse. Directed by kinesin related (kifs and in neurons especially kif5) Retrograde motors - move cargo toward end. Literal blocking, and freezing of transport because of the receptor pile up. Transport of receptors from to + end: overexpressing dyanamitin disassembles dynactin (looks like pick"s disease or ad) Dynamitin normally helps to assemble dynactin it is part of the dynein complex. It is composed of a p150 doublet, dyanamitin and cytoplasmic dynein is attached to it via the intermediate chain. How do we measure these events: there is no way to measure the production of these intracellular inclusions within intact neurons, cases about coup and contre-coup have occurred causing tbi (traumatic brain injury)
