HMB300H1 Lecture Notes - Lecture 6: Creb-Binding Protein, Histone Acetyltransferase, Synaptic Plasticity
Document Summary
Hmb300: genetic disorders affecting synapse development: common themes emerge (guest 1) The number of neurons and their complexity increases as the brain mature. The number of neurons increases during early development, but then decreases as the brain reaches a more mature state (6 14) Synaptic plasticity: synaptic plasticity is a broadly used term that is somewhat context dependent, synapses: the cleft where the pre-synaptic terminals communicate with the post synaptic terminals. In general it refers to the ability of synapses to change (broad because this can be network level, individual system of behavioural level) All of synaptic plasticity involves restructuring, but not all of it is the same. Long term potentiation: the strengthening of synapses (learning and memory) Long term depression: synaptic weakening, lack of communication: synaptic restructuring can occur through dendritic or axonal sprouting, synapse redevelopment: regeneration following injury. **synaptic plasticity is a normal phenomenon, but it is not always beneficial.
