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Class Notes for Maria Papaconstantinou

UTSGHMB321H1Maria PapaconstantinouWinter

HMB321H1 Lecture Notes - Lecture 20: Heart Development, Congenital Heart Defect, Genetic Testing

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8 Oct 2011
33
We are born with only a set number of heart muscles, which, over time, will senesce and we eventually encounter issues (e. g. cvd) We need to understan
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UTSGHMB321H1Maria PapaconstantinouWinter

HMB321H1 Lecture Notes - Lecture 17: P53, Zebrafish, Stem Cell

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8 Oct 2011
29
Genomes sequenced (easier to identify genes with mutant phenotypes) Cutting them in half will regenerate a new planarian (2 planarians) Regeneration is
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UTSGHMB321H1Maria PapaconstantinouWinter

HMB321H1 Lecture Notes - Lecture 11: Krabbe Disease, Molecular Genetics, Chromatin

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8 Oct 2011
27
*** information from the book is on the nal exam (i. e. please nish that stupid book) Big names in dna sequencing (venter, chan, steffanson, Study of p
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UTSGHMB321H1Maria PapaconstantinouWinter

HMB321H1 Lecture Notes - Lecture 13: Synteny, Gamete, Chromosome

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8 Oct 2011
24
Genes are located on different chromosomes, or they are located a great distance apart. Mendelian inheritance works if no linkage is assumed. Genes are
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UTSGHMB321H1Maria PapaconstantinouWinter

HMB321H1 Lecture Notes - Lecture 14: Genome-Wide Association Study, Snp Genotyping, Quality Control

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8 Oct 2011
30
Where a common phenotype is associated with a common variant. Thus, doing a gwas in a large cohort of individuals may be able to nd that common marker.
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UTSGHMB321H1Maria PapaconstantinouWinter

HMB321H1 Lecture Notes - Lecture 18: Adult Stem Cell, Planarian, Symmetry In Biology

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8 Oct 2011
27
Hmb321 l18: bret pearson, planarians a new model to disease and regeneration. Prebilateria (not bilaterally symmetric, e. g. sponge and jelly sh) As we
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UTSGHMB321H1Maria PapaconstantinouWinter

HMB321H1 Lecture Notes - Lecture 16: Chromatin Immunoprecipitation, Podlaska Wytwórnia Samolotów, Co-Adaptation

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8 Oct 2011
25
Paternally imprinted = expressed only from maternally inherited allele. Maternally imprinted = expressed only from paternally inherited allele. Imprint
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UTSGHMB321H1Maria PapaconstantinouWinter

HMB321H1 Lecture Notes - Lecture 15: Cpg Site, Histone Methylation, Methyl Group

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8 Oct 2011
46
Modi cations are heritable, e. g. imprinting -- without change to the dna (just additive funct"al groups) Can include methylation, histone deacetylatio
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