HMB435H1 Lecture Notes - Integrin, Hemidesmosome, Focal Adhesion

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24 Dec 2010
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HMB435H1F: ECM lecture by McCulloch
ECM ๎€ NOT an inert glue or scaffolding
๎€‚Can guide formation of capillary networks
๎€‚Mechanical: tensile and compressive strength and elasticity.
๎€‚Protection: buffer against EC change and retention of w ater.
๎€‚Organization: control cell behavior by binding growth factors and interactions with surface receptors.
Specialized Extracellular Matrices
๎€‚Matrix of bone and tooth enamel are mineralized to withstand compression
๎€‚ECM of cornea is transparent to light
๎€‚High tensile strength ECM in tendons
๎€‚Several liters of liquid ECM in blood plasma
๎€‚Most typical ECM in connective tissue, which are surrounded by specialized ECM, the BL.
๎€‚Main ECM components are GAGs, Col, elastin, FN and LN; and proteoglycans.
ECM Components
GAG: unbranched repeated disaccharides, amino sugars, sulfated acetyl-amino sugars and uronic acids.
Collagen: three -chains, which form a triple helix. Most abundant protein and provides tensile strength๎€
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Document Summary

Ecm not an inert glue or scaffolding. mechanical: tensile and compressive strength and elasticity. Protection: buffer against ec change and retention of water. organization: control cell behavior by binding growth factors and interactions with surface receptors. matrix of bone and tooth enamel are mineralized to withstand compression. Several liters of liquid ecm in blood plasma. most typical ecm in connective tissue, which are surrounded by specialized ecm, the bl. main ecm components are gags, col, elastin, fn and ln; and proteoglycans. Gag: unbranched repeated disaccharides, amino sugars, sulfated acetyl-amino sugars and uronic acids. Collagen: three -chains, which form a triple helix. under epithelial cells, coats muscle/fat cells; form glomerular filter, wraps myelin sheath. Also form barrier to certain cells, but is highway for migration. Fibronectin: cells bind to the ecm via bl or via fibronectin. Fibronectin-null mice cannot make blood vessels: provides "stickiness" to ecm.

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