HMB435H1 Lecture Notes - Integrin, Hemidesmosome, Focal Adhesion
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HMB435H1F: ECM lecture by McCulloch
ECM NOT an inert glue or scaffolding
Can guide formation of capillary networks
Mechanical: tensile and compressive strength and elasticity.
Protection: buffer against EC change and retention of w ater.
Organization: control cell behavior by binding growth factors and interactions with surface receptors.
Specialized Extracellular Matrices
Matrix of bone and tooth enamel are mineralized to withstand compression
ECM of cornea is transparent to light
High tensile strength ECM in tendons
Several liters of liquid ECM in blood plasma
Most typical ECM in connective tissue, which are surrounded by specialized ECM, the BL.
Main ECM components are GAGs, Col, elastin, FN and LN; and proteoglycans.
GAG: unbranched repeated disaccharides, amino sugars, sulfated acetyl-amino sugars and uronic acids.
Collagen: three -chains, which form a triple helix. Most abundant protein and provides tensile strength
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