HMB435H1 Lecture Notes - Integrin, Hemidesmosome, Focal Adhesion

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crimsonwombat705

24 Dec 2010

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Ecm not an inert glue or scaffolding. mechanical: tensile and compressive strength and elasticity. Protection: buffer against ec change and retention of water. organization: control cell behavior by binding growth factors and interactions with surface receptors. matrix of bone and tooth enamel are mineralized to withstand compression. Several liters of liquid ecm in blood plasma. most typical ecm in connective tissue, which are surrounded by specialized ecm, the bl. main ecm components are gags, col, elastin, fn and ln; and proteoglycans. Gag: unbranched repeated disaccharides, amino sugars, sulfated acetyl-amino sugars and uronic acids. Collagen: three -chains, which form a triple helix. under epithelial cells, coats muscle/fat cells; form glomerular filter, wraps myelin sheath. Also form barrier to certain cells, but is highway for migration. Fibronectin: cells bind to the ecm via bl or via fibronectin. Fibronectin-null mice cannot make blood vessels: provides "stickiness" to ecm.

Related Questions

Match:

( ) The ability to degrade the extracellular matrix and basal membrane in order to migrate throughout normal tissue, enter and exit vessels, and colonize a new site in the body.

( )Altering growth factors, receptors, signaling cascades, and transcription factors in order to stimulate the expression of growth promoting genes and the cell cycle.

( ) Increasing expression of proteins such as VEGF that stimulate the production of new vasculature to supply oxygen and nutrients to the tumor.

( ) Loss of function mutations in or deletion of gatekeeper and caretaker genes altering cell cycle progression and DNA damage repair pathways.

( )Altering expression of proteins and enzymes that lengthen telomeres and avoid cellular senescence.

( ) Bypassing normal cellular mechanisms that help to eliminate faulty or infected cells.

A. Enabling Replicative Immortality B. Avoiding Immune Destruction C. Deregulating Cellular Energetics D. Evading Cell Death E. Evading Growth Suppressors F. Activating Invasion and Metastasis G. Sustaining Proliferative Signaling H. Inducing Angiogenesis I. Tumor-Promoting Inflammation

rubypig988

1. Which cellular processes occur as a consequence of differential control of gene expression in eukaryotic cells?

a) Cell Differentiation

b) Differential Translation

c) Differential Polymerization

d) Differential DNA Replication

e) Differential tRNA Degradation

2) Multicellular organisms are comprised of a variety of cells with different morphologies and different functions. Which is the underlying mechanism that leads to the generation of diverse cell in one organism?

a) The expression of all genes in all cell types.

b) The duplication of the genome in certain cell types.

c) The elimination of specific group of genes from different cell types.

d) The differential expression of particular sets of genes required for a particular cellular phenotype

e) All of the above

3) Which of these statements defines paracrine cell signaling?

a)		A messenger molecule released into the blood stream to bind to a receptor on a cell far away from the release site.
b)		A messenger molecule released by a cell into the extracellular space that binds to receptors on the surface of the same cell.
c)		A messenger molecules released by a cell into the extracellular space that travels short distances to bind to a receptor in a nearby cell.
d)		A messenger molecule release by a tissue into the lumen of an organ that diffuse to bind to receptors far away from the release site.
e)		All of the above.

4) Which effect has the binding of the ligand to a G-protein coupled receptor on intracellular G-protein?

a)		ATP is hydrolyzed, activating phosphorylation
b)		GTP is exchanged for GDP on the G protein, inactivating the G protein
c)		GDP is exchanged for GTP on the G protein, activating the G protein
d)		GMP is released from the G-protein, inactivating the receptor
e)		None of the above

coffeehippopotamus191

1. Which of the following is not true of rational drug design?

a) It involves analysis of drug and receptor structure

b) It is used to develop novel drugs for diseases in which aberrant receptors have been discovered

c) It aims to maximize drug-receptor affinity

d) It aims for low drug-receptor specificity

2. Which is not a way that cells can regulate drug-receptor interactions?

		a) Down-regulation
		b)Receptor mutation
		c) Tachyphlaxis
		d) Refractory periods

3. Which is not an example of a drug-receptor interaction?

a) Alteration of urine osmolarity by mannitol

b) Inhibition of kinase activity by imatinib

Interaction between warfarin and vitamin K epoxide

d) Blockade of sodium channels by tetrodotoxin

What is true regarding induced fit?

a)		Drugs can alter the shape of their receptors
		b) Induced fit allows for extracellular signals to have intracellular effects
		c) Induced fit explains changes in the active site of enzymes following drug binding
		d) All of the above

amethystmink93

HMB435H1 Lecture Notes - Integrin, Hemidesmosome, Focal Adhesion

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