HMB435H1 Lecture : Lecture Summary

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24 Dec 2010
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Secreted proteins, 8-11 kda with c" a-helix, 3 anti-parallel b-strands, and activate gpcr and gag. Alpha or cxc: first two conserved cysteines separated, active mainly on neutrophils. Beta or cc: first two conserved cysteines adjacent; active on monocytes, lymphocytes, basophils. Chemokine receptors are specific (one chemokine), shared (several chemokines of same branch) or promiscuous (multiple chemokines across branches) Surface form is a cell adhesion molecule that induces cell activation. Soluble form attracts monocytes, nk cells, and cd8+ t lymphocyte. Fkn induces leukocyte capture since monocytes, cd8+ t cells, and nk cells adhere to fkn. Rejected grafts were harvested; immuno-stained using anti-fkn ab and compared to isograft controls. Fractalkine expression is increased in acute renal allograft rejection. Fkn-gfp is expressed in pm and in juxtanuclear compartment that overlaps but is not identical to re. Cell surface fkn is internalized and fkn co-localizes with ap-2 and clathrin. Inhibition of dynamin-1 or clathrin sirna prevents internalization of fkn.

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