HMB200 Lec-3

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Department
Human Biology
Course
HMB200H1
Professor
Ingrid L.Stefanovic
Semester
Winter

Description
Lecture 3 - Proteins and Neurons. What makes neurons special? - There are more different proteins expressed in the brain then anywhere else. - They have special proteins that allow for the speicial abilities. Its their internal special proteins that make them special. - Neurofilaments, Neurotubules, allow neurons to create their long processes and carry transmitters and signals. - Presynaptic terminals are really complex in terms of protein structure. - Special properties of axons that allow them to carry AP are Voltage gated channels and leakage channels. First, ion pumps that seperate ions, and they move back and forth via voltage gated channels and leakage channels. - The AP is carried along the surface, where the voltage channels are embedded to create a membrane potential. Voltage gates NA channel. - proposed by Hodking and Huxley in the 1950s. - A singlele transmembrane protein, a series of alpha helices, through S1 to S6 that surrond the pore when they wrap around to form a 3D structure. - lead to the understainding of how proteins fold up and make channels. How DNA makes proteins. - DNA and mRNA are easier to characterize. - Primary protein structure is the initial chain of amino acids, coming out of the ribosome. -2nday protein structure: 2 cystines create a disulfide bond (each cystine has a sulfide), allowing the creation of a secondary structure. - tertiary structure made by weaker bonds, by interactions with other amino acids. (the final organization of the protein) - whether they become membrane or cytosolic proteins is determined by whether the AA's bind to lipids or not. - hydrophilic: cytosol proteins. - hydrophobic: membrane proteins. (lipophilic) - sorting of the proteins: - voltage gated channels are concentrated in nodes of ranvier (myelinated) - the end of t
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