HMB200H1 Lecture Notes - Axon Hillock

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coppercattle724

30 Jan 2012

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Computation in single neurons: neural computation occurs in postsynaptic cells, by integration of psps (fastest & richest) & by changes in synapses (recs, enzymes slower). Based on 10s of 1000s of synapses. Still have no sure idea how thoughts are represented in neurons or circuits, only rough ideas of which brain regions are important. Doesn"t explain how thinking occurs, only how act pots generated in single neurons; gives a suggestion of how. Thoughts involve many brain areas working together in currently unknown ways conscious thinking. Act pots initated at axon hillock where voltage- gated channels concentrated; 1 act pot produced from integration. Ipsps open cl gates to keep pot ~-60. Contacts directly on dendrites or on dendritic spines. Can measure inside cell how pot flows thru cells: na ampa recs; ca nmda recs. Synapse strength: strongest near axon, usually inhibitory. Each spine produced equal synaptic effect, ~ democracy (everyone has 1 vote, small but fair effect) hillock.

Related Questions

A particular neuron (A) is post-synaptic to two other neurons (Band C). Pre-synaptic neuron B formed a synapse on the initialsegment of cell Aâs axon. Pre-synaptic neuron C formed a synapse onone of Aâs dendrites. Neuron B and neuron C produce EPSPs(excitatory postsynaptic potentials) of the same magnitudein neuron A but one of these two pre-synaptic cells affects actionpotential generation by neuron A much more than the other. Whichneuron, B or C, has the greater effect on neuron A? Explain howthis effect is generated in neuron A and why one neuron has agreater effect than the other.

acetylcholine at the neuromuscular junction causes fat, excitation, whereas at a synapse between a parasympathetic neuron and the heart, acetyl choline cause slow, inhibition. what receptors are involved and what post-synaptic events occur to allow the same neurotransmitter to have such differing effect at these two synapses.

One important observation is the structural changes seen at LTP-induced synapses. These synapses have a greater surface area with the pre-synaptic cell and have different molecular constituents. The neurons involved in LTP have more synaptic connections, too.

-What are the molecular events that cause one specific synapsis to change in relation to the others and commit to LTP? A complete answer to the question must address several aspects: mRNA transport, local protein synthesis (the proteins made and how they are made) at the synapsis and the soma, vesicle fusion, receptor transport.

HMB200H1 Lecture Notes - Axon Hillock

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