HMB200H1 Lecture Notes - Ganglion, Pituitary Gland, Hypothalamus

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12 Mar 2012
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Many forms: monoamines (ex. epinephrine, peptides (most common; ex. Many hormones are also transmitters: epinephrine, cholecystokinin (cck) larger (8 aas) Many brain sites have recs, esp in gaba neurons in limbic: corticotropin releasing hormone (crh) Release of steroid hormones from adrenal gland. Same molec, can have dif fns in dif brain areas: ex. Ne, epinephrine (adrenal medulla: hormone circulates in bloodstream, transmitter acts locally by release into specific brain site. Pheromones: distributed by airborne communication btwn animals as opposed to within own body. Serine, tyrosine prot hormones: have many binding sites if big, recs for polypeptides 2 types. Monoamine amine grp connected to ring structure. Steroid hormones = lipophilic, can pass thru cell membrane. Steroid recs intracellular, slow diffusion act slowly. Don"t want to mix up transmitter & hormone effects segregate peripheral & central effects. Regulate circulating hormones by pit gland via (-) fdbk. Changes metabolic rate, bhvr: too much disorganization of bhvr & body anatomy must be turned off.

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