HMB265H1 Lecture : Notes taken during lecture

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redtermite204

14 Jan 2011

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Sliding scale for any range of phenotypes for instance diseases. Some diseases have strong, simple genetic basis, no major role for environment. heart disease and diabetes genetic and environmental component. Important for mendel to look at simple traits to understand inheritance. Agriculture cattle and crops with favourable traits chosen to breed. These questions had no answers until mendel"s paper. Rapid generation time so can look at generations; maturation time from baby to adult in short span of time. Look the same every generation highly homozygous in these lines. Also important that peas/models have discrete options for traits. Long v. short stems discrete type of inheritance. Dominance all of plants were one phenotype. In f1 generation, trait present is called dominant; missing trait is recessive. Green, recessive, appeared in next generation no mixing of the two colours, into an intermediate colour that persisted into the next generations. Basic idea that adult plant that makes yellow seeds.

Related Questions

Choose a trait that goes beyond Mendelâs one trait inheritance. Discuss the inheritance (ex. Incomplete dominance, multiple allele, polygenic, pleiotrophy, linkage, environmental influences), the different phenotypes or anything else that deviates from simple genetics. Mendel got lucky with the traits he chose in his pea plants. If he got more complicated traits and inheritance it would have made his findings almost impossible to come to. Talk about how these traits would have made it hard for scientists like Mendel to figure out inheritance the way he did.

When Gregor Mendel was developing his ideas of inheritance of characteristics, molecular genetics was not yet discovered. Explain in your own terms, why his two most important ant laws have stood the test of time. What assumptions about them were correct? Describe a scenario in which patterns of inheritance did NOT adhere to Mendelian genetics.

Are the following genetic mutation positive for the 3 characteristics listed below - Phenylketonuria (PKU), Smith-Lemli-Opitz syndrome (SLOS), Alzheimerâs disease, Sickle cell anemia?

1. It is inherited (at least in some individuals or families) as a single-gene disorder (this means that a disorder where many cases are due to a mix of multiple contributing genes and environmental factors, such as heart disease or Alzheimerâs, could still be chosen if you focus on those instances with a single-gene cause)

2. It demonstrates at least one non-Mendelian characteristic (incomplete penetrance, variable expressivity, sex inflence, sex limited multiple alleles, or incomplete dominance) in its inheritance pattern

3. It is caused by mutations in a gene that has been identified and characterized.

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HMB265H1 Lecture : Notes taken during lecture

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