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HMB265H1 (242)
Lecture

Lecture 4

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Department
Human Biology
Course
HMB265H1
Professor
Stephen Wright
Semester
Winter

Description
Lecture 426 Human Pedigree AnalysisHuman matingsprovide examples of singlegene inheritance BUT cant do experiments so have to look at medical recordsPEDIGREE ANALYSIS deducing singlegene inheritance of human phenotypes by a study of the progeny of mating wi a family often stretching back many generations scrutiny of records do matingsPROPOSITUS In a human pedigree the person which first came to the attention of the geneticists usually the phenotype of the propositus exceptional in some wayTo see singlegene inheritance the patterns in the pedigree have to be interpreted according to Mendels law of segregation BUT humansfew kids31 ratios11 ratios not usually seen until many similar pedigrees are combinedAutosomal Recessive Disordersthe affected phenotype of an autosomal recessive disorder is inherited as a recessive alleleunaffected
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