HMB265H1 Lecture : Notes taken during lecture

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11 Feb 2011
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HMB265H1 Full Course Notes
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HMB265H1 Full Course Notes
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use closest markers to give the most accurate genetic maps: so double recombinant not hidden. Fewer crossover than expected under assumption of independence. presumably due to some physical interference: crossover here makes crossover somewhere nearby more difficult. only one gene order makes these types the rarest. Most common types are parental if linked, double crossovers rarest. Determining gene order and distance corresponds well with physical distance. centromere physical space but recombination suppressed here: genetic and physical distance doesn"t correspond here well. Recombination mapping key in genetics, disease genetics, evolutionary, developmental genetics . can locate gene that confers the particular phenotype without knowing the gene beforehand. segregation of genetically based phenotype and find where it is located in proximity to other molecular markers and genes made possible by mapping: linkage mapping identifies location. align where particular disease is and find genetic space address, link it to physical space address.

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