Lecture 13

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Department
Human Biology
Course
HMB321H1
Professor
Maria Papaconstantinou
Semester
Winter

Description
4 MAR 2011HMB321 L13 Linkage GeneticsAssumptions of independent assortmentGenes are located on different chromosomes or they are located a great distance apartMendelian inheritance works if no linkage is assumedTH MorganPrincipal of linkageTheory of sexlinked inheritanceLinkageGenes are linked if they were located near each other syntenic genesDistance between genesThe further the genes are in a chromosome the higher the recombination frequency it has therefore the less linkage the two are encounteringThe closer the higher the linkage the less recombination ie Less independent assortmentRefer to slides for Distance of Recombination calculationCase StudyDistance recombinant gametestotal of gametes x 100Recombining gametes1 out of the affected 7 with BO143143cM distanceReal answer10cM10 potentials for recombination do not count those that married inAnd only 1 unaffected out of 10 progeny
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