HMB321H1 Lecture Notes - Lecture 16: Chromatin Immunoprecipitation, Podlaska Wytwórnia Samolotów, Co-Adaptation
8 Oct 2011
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Document Summary
Paternally imprinted = expressed only from maternally inherited allele. Maternally imprinted = expressed only from paternally inherited allele. Imprinting in the germ line = imprint removal and then re-application by sex. Imprinting maintains as it continues into development from child => adult. Competing interests between mother and father"s resources, i. e. paternal genes are trying to draw resources from mother for this progeny; maternal genes are trying to conserve resources for future pregnancies. If imprinted allele is normal + expressed is mutant = no homologous copy; no wt + If mother is affected for a maternally imprinted gene (paternal inherited copy expressed is mutant) => will produce carriers because her copy will be imprinted anyways. However, her sons will have affected children because they can inherit either a mutant or wt allele, both of which are expressed because it is maternally imprinted and not paternally imprinted + paternally re-set.
