Class Notes (836,615)
Canada (509,866)
HMB435H1 (4)
Lecture

Lecture Summary

2 Pages
131 Views
Unlock Document

Department
Human Biology
Course
HMB435H1
Professor
M.Cybulsky
Semester
Fall

Description
Integrin and leukocyte moving: Cybalsky lecture Leukocyte emigration can be subdivided into a series of steps or stages: tetheringrolling (transient adhesive interactions) arrest Firm or stable adhesion (leukocyte flattening or spreading) Intravascular crawling transendothelial migration or diapedesis (migration between or through endothelial cells) Endothelial Cell Activation Inflammatory IL-1TNFa activate endothelial cells to express adhesion molecules: Selectins: (E-selectin), platelet (P-selectin) and leukocyte (L-selectin) Selectin ligands: sLeX on PSGL-1 Immunoglobulin gene superfamily: ICAM-1, ICAM-2, VCAM-1 Integrins: 2 and 4 Selectins and ligands: Contain a calcium-dependent lectin domain with an adjacent EGF-like domain The
More Less

Related notes for HMB435H1

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit