HMB441H1 Lecture Notes - Lecture 8: Protein Tyrosine Phosphatase, Collagen, Rheumatoid Arthritis
16 Dec 2012
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Document Summary
Etiology is not simple multigenic and there are several environmental factors. Most research is focusing on genetic factors because envir. is hard to research (e. g. imagine tracking a persons total diet over 15 years) Immune system targets lining of joints (synovial) and eats it up, then moves onto the cartilage which causes bone to rub on bone. Limitations to linkage requirement for multicase families, limited resolution. Some of the genes are shared between different autoimmune diseases. Some people get benign symptoms and others get severe ones (e. g. goes on to perhaps affect other organs) Before, robots would not analyze base pairs but now can analyze thousands a second. To try and find markers for autoimmune disease we must collect controls and people affected and compare to find markers for it. Moved from knowing one gene for ra, to 25 known genes now. Ptpn22 gene first seen in type 1 diabetes, then found in ra and numerous others.
