IMM250H1 Lecture : Lecture notes.doc
19 Dec 2012
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Black death/ bubonic plague: responsible for 30 60% of european deaths from 1350 1400. Vector an organism that carries a causative agent for infection: the disease vector for the bubonic plague was yersinia pestis, rats carried the fleas, which harboured the yersinia pestis bacterium. There may have been proof of immune mediated tolerance (a receptor mutation) associated with the bubonic plague, found out through retrospective studies. Abu bakr ibn zakaria razi: first to distinguish smallpox and measles, and the first to characterize asthma as a disease. Avicenna: known as the father of modern medicine. Insights on how to run a clinical trial, experimental medicine procedures, evidence based medicine and categorized the nature of infectious diseases: acquired immunity: the ability to resist re-infection from a known pathogen. In 1796, he inoculated an 8 year old child with the milder smallpox virus from the milkmaids, and subsequently exposed the child to the smallpox virus.
