IMM250H1 Lecture Notes - Lecture 7: Reverse Transcriptase, Gp41, Envelope Glycoprotein Gp120

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14 Apr 2013
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Hiv = retrovirus = rna virus = rna is infectious. Make vaccine that interfere with viral life cycle but not host (rna dna does not happen in host cells) Highly related virus with the same symptoms but present in different species. No hiv epidemic because transmission of hiv is limited. We must continue to vaccinate the human population. Reverse transcriptase (rna as template dna) Gp41 and gp120 are encoded by hiv. 30% of genome is made of provirus (double stranded dna integrated into host chromosome) Slide 11 hiv infection of target cells. Gp120 (hiv) binds to cd4 (t cells) Gp120 (hiv) binds to ccr5 or cxcr4 (t cells) Gp41 (hiv) binds and fuses with membrane. Slide 13 reverse transcription of viral rna (rna dna) Reverse transcriptase is one of the original targets for retrovirus. Slide 15 proviral dna is transcribe to generate viral rna and proteins. 5" ltr contains strong promoter sequences that drive the transcription of genes.

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