IMM250H1 Lecture 1: imm250 lec 1
Different protein structure
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Esp. viruses like HIV/ AIDS
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Can also mutate and evolve to not be recognized by
immune system
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Challenge: variation in pathogens
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Recognition
Like an e.coli that was affecting lettuce in burgers
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Pathogens give out toxins and replicate quickly so response
needs to be quick
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Also infection can be anywhere in body --> immune system
needs to survey everything
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Response
Risk of immune induced disease
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Want to go back to resting state
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Collateral damage caused by whatever body is doing to try to get
rid of disease
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Return to resting
General overview of immune system
Size goes from small to large
Ex of virus = influenza
Bacteria = prokaryote
Floating DNA in cytoplasm
Fungus = eukaryote
Ex: candida
Can also be unicellular, yeast form
2 or more hosts like malaria
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Have to adapt to both types of hosts
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Transmitted by MOSQUITOs to HUMANS
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Protozoa
Can be very big
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Like tapeworm
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Multicellular parasites
January 10, 2018
9:03 AM
imm250 lec 1 Page 1
Acidic stomach
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Mucous membranes
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Immediate effect
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Barriers
Already there
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Quick
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First step
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Innate immunity
After the infection
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Memory cells
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Adaptive immunity
Unusual because it didn't affect animals / humans were the only
target of the virus
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Killed 1/3 of population in Europe in 1700s
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Brought to mexico by spanish colonists
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1776: smallpox outbreak was an important factor in the american
defeat in the battle of quebec
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Scratch material with smallpox into the skin of person
imm250 lec 1 Page 2
Document Summary
Have to adapt to both types of hosts. Can also mutate and evolve to not be recognized by immune system. Pathogens give out toxins and replicate quickly so response needs to be quick. Like an e. coli that was affecting lettuce in burgers. Also infection can be anywhere in body --> immune system needs to survey everything. Collateral damage caused by whatever body is doing to try to get rid of disease imm250 lec 1 page 1. Unusual because it didn"t affect animals / humans were the only target of the virus. Killed 1/3 of population in europe in 1700s. 1776: smallpox outbreak was an important factor in the american defeat in the battle of quebec. Scratch material with smallpox into the skin of person imm250 lec 1 page 2. Scratch material with smallpox into the skin of person being inoculated. Most survived and were immune to virulent smallpox. In 1980, who said it was eradicated from earth.
