IMM250H1 Lecture Notes - Lecture 7: T Helper 17 Cell, Antigen, Skin Grafting
Document Summary
All lymphoctyes must go through this 3 stage process. Cell-cell contact is something that is provided by the apc. Na ve t cells needs an antigen presenting cell. This antigen presenting cell needs to help the t cells understand whats going on. It must process and present the antigen in class 1 or 2. The second thing they have to do is show the t cells whats out there i(cid:374) the tissue, (cid:271)ut also tell its it"s a pro(cid:271)le(cid:373). T (cid:272)ells (cid:272)a(cid:374)t re(cid:272)og(cid:374)ize da(cid:374)ger, apc"s tell the t (cid:272)ells that there is a threat. Apc"s se(cid:374)se da(cid:374)ger (cid:449)ith pprs, a(cid:374)d when they sense danger they release cositulatory molecules. Professional apcs are dendritic cells, macrophahes a(cid:374)d b (cid:272)ells. B (cid:272)ells do(cid:374)"t e(cid:454)press (cid:272)osti(cid:373)ulator(cid:455) (cid:373)ole(cid:272)ules (cid:271)e(cid:272)ause the(cid:455) are(cid:374)"t part of the i(cid:374)(cid:374)ate i(cid:373)(cid:373)u(cid:374)it(cid:455), the(cid:455) do(cid:374)"t re(cid:272)og(cid:374)ize prrs. Thus, o(cid:374)l(cid:455) de(cid:374)driti(cid:272) (cid:272)ells (cid:272)a(cid:374) a(cid:272)ti(cid:448)ate the na ve t cell response.
