IMM250H1 Lecture Notes - Lecture 5: Antigen, Immunoglobulin Light Chain, White Blood Cell

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22 Feb 2018
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Contrast innate and adaptive immune system (new info) Innate: only recognizes common molecular patters, pamps using prrs leukocytes, adaptive recognize any molecular patter, antigens (macromolecules) using antigen receptors lymphocytes. Can bodily cells have antigens: yes, major driver in auto immune diseases. Can transplanted tissues have antigens: yes - neo antigens. What do t cells do: binds to peptide antigen that need not be on the surface of the pathogen that fits tcr and then secrete cytokines and molecular killers. What do b cells do: binds to protein/carbohydrate antigen that"s on the surface that fits bcr and secretes antibodies which are soluble bcrs. What is the stricture of bcr: y - chain that binds 2 antigens at light chains (gamma/lamba) and a tm heavy chain. What is the stricture of tcr: a pair of parallel alpha and beta chains. How is this possible given that we only have 25 thousand genes: gene rearrangement.

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