IMM250H1 Lecture Notes - Lecture 5: Complementarity-Determining Region, Tak Wah Mak, Severe Combined Immunodeficiency

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23 Apr 2018
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High inflammation that starts in innate immunity triggers adaptive immunity. The innate immune system cells recognize pamps using prrs. In the adaptive system, lymphocytes recognize antigens using antigen receptors (antigens are macromolecules recognized by lymphocytes and are pathogen-specific, a pathogen has multiple antigens, only expressed in vertebrates but all of the animal kingdom expresses innate immunity. Lymphoid stem cells make up the cells of the adaptive immune system. T and b cells recognize antigens via b/t cell receptors. T lymphocytes become killers and create cytokine, and b lymphocytes release antibodies to neutralize toxins and can be expressed on the surface of b cells. Bcr (b cell receptor) has a light chain and a heavy chain, looks like the letter y, it has 4 proteins, can bind 2 antigens. Tcr (t cell receptor) has an alpha chain and a beta chain, and can only bind 1 antigen. B cell antigens must be on the pathogen surface.

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