IMM250H1 Lecture Notes - Lecture 8: Immunoglobulin Light Chain, Cell Culture, B Cell
Document Summary
Le(cid:272)ture 8: anti(cid:271)ody responses in host defense and medi(cid:272)ine. How antibodies are generated: recall; dcs present to t cells (mhc class. Ii cd4+t cells and mhc class i . Cd8+t cells) cd4+ t cells differentiate to th cells cytokines from dc (il-12, il- 4, il-6, il-23) cause th to differentiate in. Igm is the default isotype made prior to switching: a given b cell makes one antibody class at any given time. Isotype switching requires cytokines from tfh and/or microenvironment. Antibodies in primary vs memory response in primary response igm dominates. In memory response igg and iga dominate with higher affinity. Igd on the b cell surface plays a role in maturation but secreted igd is uncommon and its biological role is unclear. Igm is in blood and can enter tissues at sites of inflammation. Iga is found in body secretion (mucus, tears, saliva, breast milk, etc)