IMM250H1 Lecture Notes - Lecture 3: Innate Immune System, Pathogenic Bacteria, Bacterial Adhesin

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29 Nov 2018
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Lecture 3 - innate immunity: first line of defense. Pathogens that are too big to be ingested, release granules. Property: encoded in pathogenicity islands; mobile (can go from non-patho to a patho one) If the innate immune system is not able to tackle, they can cause infection. Koch"s postulate: criteria to establish a causative relationship btw pathogen and disease: microbe found in all cases of disease, insulated microbe grown in vitro, when transferred to healthy animal, sick, microbe found again in those infected animals. Pathogenic bacteria (never part of normal flora, may cause subclinical infection) Part of normal flora, when extra vf accruired become pathogenic. Part of normal flora, access to deep tissue disease. In immunocompromised patient, normal flora bacteria disease. In develped countries infectious disease decreased but still a major cause of death worldwide. Growing recognition of link between microbes and chronic disease. Hodgkin lymphoma, burkitt lymphoma: epstein barr virus. Zoonosis: disease spread from animals to humans.

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